DOMINANT RP IN THE MIDDLE WHILE RECESSIVE IN BOTH THE N- AND C-TERMINALS DUE TO RP1 TRUNCATIONS: CONFIRMATION, REFINEMENT, AND QUESTIONS

Dominant RP in the Middle While Recessive in Both the N- and C-Terminals Due to RP1 Truncations: Confirmation, Refinement, and Questions

RP1 truncation variants, including frameshift, nonsense, and splicing, are a common cause of retinitis pigmentosa (RP).RP1 is a unique gene where truncations cause either autosomal dominant RP (adRP) or autosomal recessive RP (arRP) depending on the location of the variants.This study aims to clarify the boundaries between adRP and arRP caused by R

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The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior.Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established.However, the implications of its receptors in lung adenocarcinoma have so far remained

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